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camps rp  (MedChemExpress)


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    MedChemExpress camps rp
    (A) Representative raw traces of mEPSCs of Empty Vector (CTRL) and Syt1 variant (N341S) neurons following acute 1 hr treatment with vehicle (VEH), TTX, or TTX+AP5 treatment. (B) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.120; VEH vs. TTX+APV of CTRL p=0.006; VEH vs. TTX of N341S p=0.050; VEH vs. TTX+APV of N341S p=0.796, N=2, n=6-7 per group). (C) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.986; VEH vs. TTX+APV of CTRL p=0.991; VEH vs. TTX of N341S p=0.519; VEH vs. TTX+APV of N341S p=0.276, N=2, n=6-7 per group). (D) Representative raw traces of mEPSCs of empty vector (CTRL) and Syt1 variant (N341S) neurons after chronic 48 hr DMSO <t>and</t> <t>cAMPS-RP</t> treatment. (E) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.007; DMSO vs. cAMPS-RP of N341S p=0.865; N=2-3, n=7-14 per group). (F) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.170; DMSO vs. cAMPS-RP of N341S p=0.856; N=2-3, n=7-14 per group).
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    Images

    1) Product Images from "Regulation of spontaneous neurotransmission and homeostatic synaptic plasticity by synaptotagmin-1 disease variants at the SNARE primary interface"

    Article Title: Regulation of spontaneous neurotransmission and homeostatic synaptic plasticity by synaptotagmin-1 disease variants at the SNARE primary interface

    Journal: bioRxiv

    doi: 10.64898/2026.02.17.706274

    (A) Representative raw traces of mEPSCs of Empty Vector (CTRL) and Syt1 variant (N341S) neurons following acute 1 hr treatment with vehicle (VEH), TTX, or TTX+AP5 treatment. (B) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.120; VEH vs. TTX+APV of CTRL p=0.006; VEH vs. TTX of N341S p=0.050; VEH vs. TTX+APV of N341S p=0.796, N=2, n=6-7 per group). (C) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.986; VEH vs. TTX+APV of CTRL p=0.991; VEH vs. TTX of N341S p=0.519; VEH vs. TTX+APV of N341S p=0.276, N=2, n=6-7 per group). (D) Representative raw traces of mEPSCs of empty vector (CTRL) and Syt1 variant (N341S) neurons after chronic 48 hr DMSO and cAMPS-RP treatment. (E) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.007; DMSO vs. cAMPS-RP of N341S p=0.865; N=2-3, n=7-14 per group). (F) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.170; DMSO vs. cAMPS-RP of N341S p=0.856; N=2-3, n=7-14 per group).
    Figure Legend Snippet: (A) Representative raw traces of mEPSCs of Empty Vector (CTRL) and Syt1 variant (N341S) neurons following acute 1 hr treatment with vehicle (VEH), TTX, or TTX+AP5 treatment. (B) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.120; VEH vs. TTX+APV of CTRL p=0.006; VEH vs. TTX of N341S p=0.050; VEH vs. TTX+APV of N341S p=0.796, N=2, n=6-7 per group). (C) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.986; VEH vs. TTX+APV of CTRL p=0.991; VEH vs. TTX of N341S p=0.519; VEH vs. TTX+APV of N341S p=0.276, N=2, n=6-7 per group). (D) Representative raw traces of mEPSCs of empty vector (CTRL) and Syt1 variant (N341S) neurons after chronic 48 hr DMSO and cAMPS-RP treatment. (E) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.007; DMSO vs. cAMPS-RP of N341S p=0.865; N=2-3, n=7-14 per group). (F) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.170; DMSO vs. cAMPS-RP of N341S p=0.856; N=2-3, n=7-14 per group).

    Techniques Used: Plasmid Preparation, Variant Assay, Comparison



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    (A) Representative raw traces of mEPSCs of Empty Vector (CTRL) and Syt1 variant (N341S) neurons following acute 1 hr treatment with vehicle (VEH), TTX, or TTX+AP5 treatment. (B) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.120; VEH vs. TTX+APV of CTRL p=0.006; VEH vs. TTX of N341S p=0.050; VEH vs. TTX+APV of N341S p=0.796, N=2, n=6-7 per group). (C) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.986; VEH vs. TTX+APV of CTRL p=0.991; VEH vs. TTX of N341S p=0.519; VEH vs. TTX+APV of N341S p=0.276, N=2, n=6-7 per group). (D) Representative raw traces of mEPSCs of empty vector (CTRL) and Syt1 variant (N341S) neurons after chronic 48 hr DMSO <t>and</t> <t>cAMPS-RP</t> treatment. (E) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.007; DMSO vs. cAMPS-RP of N341S p=0.865; N=2-3, n=7-14 per group). (F) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.170; DMSO vs. cAMPS-RP of N341S p=0.856; N=2-3, n=7-14 per group).
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    (A) Representative raw traces of mEPSCs of Empty Vector (CTRL) and Syt1 variant (N341S) neurons following acute 1 hr treatment with vehicle (VEH), TTX, or TTX+AP5 treatment. (B) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.120; VEH vs. TTX+APV of CTRL p=0.006; VEH vs. TTX of N341S p=0.050; VEH vs. TTX+APV of N341S p=0.796, N=2, n=6-7 per group). (C) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.986; VEH vs. TTX+APV of CTRL p=0.991; VEH vs. TTX of N341S p=0.519; VEH vs. TTX+APV of N341S p=0.276, N=2, n=6-7 per group). (D) Representative raw traces of mEPSCs of empty vector (CTRL) and Syt1 variant (N341S) neurons after chronic 48 hr DMSO <t>and</t> <t>cAMPS-RP</t> treatment. (E) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.007; DMSO vs. cAMPS-RP of N341S p=0.865; N=2-3, n=7-14 per group). (F) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.170; DMSO vs. cAMPS-RP of N341S p=0.856; N=2-3, n=7-14 per group).
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    (A) Representative raw traces of mEPSCs of Empty Vector (CTRL) and Syt1 variant (N341S) neurons following acute 1 hr treatment with vehicle (VEH), TTX, or TTX+AP5 treatment. (B) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.120; VEH vs. TTX+APV of CTRL p=0.006; VEH vs. TTX of N341S p=0.050; VEH vs. TTX+APV of N341S p=0.796, N=2, n=6-7 per group). (C) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.986; VEH vs. TTX+APV of CTRL p=0.991; VEH vs. TTX of N341S p=0.519; VEH vs. TTX+APV of N341S p=0.276, N=2, n=6-7 per group). (D) Representative raw traces of mEPSCs of empty vector (CTRL) and Syt1 variant (N341S) neurons after chronic 48 hr DMSO <t>and</t> <t>cAMPS-RP</t> treatment. (E) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.007; DMSO vs. cAMPS-RP of N341S p=0.865; N=2-3, n=7-14 per group). (F) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.170; DMSO vs. cAMPS-RP of N341S p=0.856; N=2-3, n=7-14 per group).
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    (A) Representative raw traces of mEPSCs of Empty Vector (CTRL) and Syt1 variant (N341S) neurons following acute 1 hr treatment with vehicle (VEH), TTX, or TTX+AP5 treatment. (B) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.120; VEH vs. TTX+APV of CTRL p=0.006; VEH vs. TTX of N341S p=0.050; VEH vs. TTX+APV of N341S p=0.796, N=2, n=6-7 per group). (C) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.986; VEH vs. TTX+APV of CTRL p=0.991; VEH vs. TTX of N341S p=0.519; VEH vs. TTX+APV of N341S p=0.276, N=2, n=6-7 per group). (D) Representative raw traces of mEPSCs of empty vector (CTRL) and Syt1 variant (N341S) neurons after chronic 48 hr DMSO <t>and</t> <t>cAMPS-RP</t> treatment. (E) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.007; DMSO vs. cAMPS-RP of N341S p=0.865; N=2-3, n=7-14 per group). (F) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.170; DMSO vs. cAMPS-RP of N341S p=0.856; N=2-3, n=7-14 per group).
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    (A) Representative raw traces of mEPSCs of Empty Vector (CTRL) and Syt1 variant (N341S) neurons following acute 1 hr treatment with vehicle (VEH), TTX, or TTX+AP5 treatment. (B) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.120; VEH vs. TTX+APV of CTRL p=0.006; VEH vs. TTX of N341S p=0.050; VEH vs. TTX+APV of N341S p=0.796, N=2, n=6-7 per group). (C) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.986; VEH vs. TTX+APV of CTRL p=0.991; VEH vs. TTX of N341S p=0.519; VEH vs. TTX+APV of N341S p=0.276, N=2, n=6-7 per group). (D) Representative raw traces of mEPSCs of empty vector (CTRL) and Syt1 variant (N341S) neurons after chronic 48 hr DMSO <t>and</t> <t>cAMPS-RP</t> treatment. (E) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.007; DMSO vs. cAMPS-RP of N341S p=0.865; N=2-3, n=7-14 per group). (F) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.170; DMSO vs. cAMPS-RP of N341S p=0.856; N=2-3, n=7-14 per group).
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    Image Search Results


    (A) Representative raw traces of mEPSCs of Empty Vector (CTRL) and Syt1 variant (N341S) neurons following acute 1 hr treatment with vehicle (VEH), TTX, or TTX+AP5 treatment. (B) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.120; VEH vs. TTX+APV of CTRL p=0.006; VEH vs. TTX of N341S p=0.050; VEH vs. TTX+APV of N341S p=0.796, N=2, n=6-7 per group). (C) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.986; VEH vs. TTX+APV of CTRL p=0.991; VEH vs. TTX of N341S p=0.519; VEH vs. TTX+APV of N341S p=0.276, N=2, n=6-7 per group). (D) Representative raw traces of mEPSCs of empty vector (CTRL) and Syt1 variant (N341S) neurons after chronic 48 hr DMSO and cAMPS-RP treatment. (E) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.007; DMSO vs. cAMPS-RP of N341S p=0.865; N=2-3, n=7-14 per group). (F) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.170; DMSO vs. cAMPS-RP of N341S p=0.856; N=2-3, n=7-14 per group).

    Journal: bioRxiv

    Article Title: Regulation of spontaneous neurotransmission and homeostatic synaptic plasticity by synaptotagmin-1 disease variants at the SNARE primary interface

    doi: 10.64898/2026.02.17.706274

    Figure Lengend Snippet: (A) Representative raw traces of mEPSCs of Empty Vector (CTRL) and Syt1 variant (N341S) neurons following acute 1 hr treatment with vehicle (VEH), TTX, or TTX+AP5 treatment. (B) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.120; VEH vs. TTX+APV of CTRL p=0.006; VEH vs. TTX of N341S p=0.050; VEH vs. TTX+APV of N341S p=0.796, N=2, n=6-7 per group). (C) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Dunnett’s multiple comparisons test: VEH vs. TTX of CTRL p=0.986; VEH vs. TTX+APV of CTRL p=0.991; VEH vs. TTX of N341S p=0.519; VEH vs. TTX+APV of N341S p=0.276, N=2, n=6-7 per group). (D) Representative raw traces of mEPSCs of empty vector (CTRL) and Syt1 variant (N341S) neurons after chronic 48 hr DMSO and cAMPS-RP treatment. (E) Comparison of mean baseline mEPSC amplitude (pA) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.007; DMSO vs. cAMPS-RP of N341S p=0.865; N=2-3, n=7-14 per group). (F) Comparison of mean baseline mEPSC frequency (Hz) for each group after incubations (Two-way ANOVA with Sidak’s multiple comparisons test: DMSO vs. CAMPS-RP of CTRL p=0.170; DMSO vs. cAMPS-RP of N341S p=0.856; N=2-3, n=7-14 per group).

    Article Snippet: To model homeostatic plasticity using chronic pharmacological effect, neurons were incubated for 48 hours with cAMPS-RP (MedChemExpress).

    Techniques: Plasmid Preparation, Variant Assay, Comparison